The FGK4.5 monoclonal antibody reacts with mouse CD40 also known as Bp50. CD40 is a 48 kDa type I transmembrane glycoprotein that belongs to the tumor necrosis factor receptor (TNFR) superfamily. CD40 is expressed broadly on antigen-presenting cells (APCs) such as dendritic cells, B cells, macrophages, and monocytes as well as non-immune endothelial cells, basal epithelial cells, and a range of tumors. Upon binding to its ligand CD154, CD40 acts as a costimulatory molecule for the activation of B cells, dendritic cells, monocytes, and other APCs. CD40 plays roles in B cell activation, differentiation, proliferation and Ig isotype switching as well as dendritic cell maturation. Agonistic CD40 monoclonal antibodies have been shown to activate APCs and promote anti-tumor T cell responses. The FGK4.5 antibody is an agonistic antibody that has been shown to activate CD40 expressing APCs. FGK4.5 can also be used to inhibit CD40/CD154 interaction in vitro and in vivo.

產(chǎn)品名稱(chēng):InVivoMab anti-mouse CD40

反應(yīng)種屬:mouse

宿主來(lái)源:rat

實(shí)驗(yàn)應(yīng)用:in vivo CD40 activation, in vitro B cell stimulatioN/Activation

同種型:IgG2a

免疫原:Recombinant mouse CD40 fusion protein

克隆性:Monoclonal

克隆號(hào):FGK4.5/FGK45

產(chǎn)品濃度:Lot specific,typically between 4-11 mg/ml

保存溫度:Undiluted at 4°C in the dark

運(yùn)輸溫度:Ship with adequate amount of blue ice to ensure the product remains at 4°C for the duration of transit

預(yù)期分子量:150 kDa

產(chǎn)品形式:液體

有效期:One year from the date of receipt if stored as recommended

產(chǎn)地:美國(guó)

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